A minimal model for spontaneous cell polarization and edge activity in oscillating, rotating and migrating cells
نویسندگان
چکیده
Franck Raynaud, Mark E. Ambühl ∗,1 Chiara Gabella, Alicia Bornert, Ivo F. Sbalzarini, 3 Jean-Jacques Meister, and Alexander B. Verkhovsky Laboratory of Cell Biophysics, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland MOSAIC Group, Chair of Scientific Computing for Systems Biology, Faculty of Computer Science, TU Dresden, D-01069 Dresden, Germany MOSAIC Group, Center for Systems Biology Dresden, Max Planck Institute of Molecular Cell Biology and Genetics, D-01307 Dresden Germany
منابع مشابه
The Assessment of NK Cytotoxicity and CD56+/CD16+ Phenotype by Flowcytometry in PBL Isolated from Women with Recurrent Spontaneous Abortion
Background: Human peripheral blood NK cells constitutively express CD56 and CD16 antigens. Peripheral blood NK cells seem to be strongly related with decidual NK cells, and may reflect the decidual NK cell functional status. There are varied reports concerning the relationship between NK cell cytotoxicity in women with recurrent spontaneous abortion. Objective: To study NK activity in women wit...
متن کاملPolarization of Migrating Monocytic Cells Is Independent of PI 3-Kinase Activity
BACKGROUND Migration of mammalian cells is a complex cell type and environment specific process. Migrating hematopoietic cells assume a rapid amoeboid like movement when exposed to gradients of chemoattractants. The underlying signaling mechanisms remain controversial with respect to localization and distribution of chemotactic receptors within the plasma membrane and the role of PI 3-kinase ac...
متن کاملModeling and simulation of a new architecure stack applied on the PEM Fuel Cell
To simulate a new economical architecture for PEM fuel cell and investigate the effectiveness of the introduced structure on the performance, computational fluid dynamics (CFD) code is used to solve the equations for a single domain of the cell namely: the flow field, the mass conservation, the energy conservation, the species transport, and the electric/ionic fields under the assumptions of st...
متن کاملChemokine-Dependent pH Elevation at the Cell Front Sustains Polarity in Directionally Migrating Zebrafish Germ Cells
Directional cell migration requires cell polarization with respect to the distribution of the guidance cue. Cell polarization often includes asymmetric distribution of response components as well as elements of the motility machinery. Importantly, the function and regulation of most of these molecules are known to be pH dependent. Intracellular pH gradients were shown to occur in certain cells ...
متن کاملP 18: Alterations of Electrophysiological Activity of Cerebellar Pukinje Cells of Rats Under Harmaline Toxicity
Introduction: Beta-carboline alkaloids of P. harmala are shown to have immune-modulatory effects in several studies. Extracts of this plant have significant anti-inflammatory effect via the inhibition of some inflammatory mediators including PGE2 and TNF-α. In postmortem studies, structural alterations to the cerebellum have been recognized, including Purkinje cell loss being re...
متن کامل